This guide doesn't deal with Pipewire but it's still useful for general Linux Audio tuning, since most Linux distros are not tuned for audio production. http://tedfelix.com/linux/linux-midi.html

What I do is to install RNC (Rui Nuno Capela) rtirq, then configure it (especially parameters in RTIRQ_NAME_LIST="snd usb i8042") The order of the entries determine which device gets higher priority.

Can anyone tell me how to use pipewire in interrupt driven mode?  IRQ?

Here are some Linux Audio packages compiled for Ubuntu Focal / Mint 20 https://disk.yandex.com/d/p8I8A0TIiJBJkA *Current contents* Emu0404 Alsa Firmware Linux Sampler 2.2.0 Calf 0.90.3 Guitarix LV2